The article presents the results of an analytical review of available data on complications of twin pregnancy and management tactics. The main complications of twin pregnancy: preterm birth/ delivery, low birth weight of the newborn, retardation of fetal development, preeclampsia, gestational diabetes, placental abruption; fetal death/loss, caesarean section. Pregnancy with twins is associated with many problems and controversies. Efforts to standardize diagnostic criteria and reporting results,
as well as the development of national and international practice guidelines, will help improve research and clinical practice. The global binary and multiple prioritization partnership also identified the most pressing research uncertainties identified by both physicians and pregnant women. However, more rigorous studies in the form of randomized control studies or large well-conducted cohort studies are still needed to resolve many of these controversies, provide optimal care, and further improve the outcomes of twin pregnancies.
Hamilton BE, Martin JA, Osterman MJK, Curtin SC, Matthews TJ. Births: final data for 2015 Natl Vital Stat Rep. 2017; 66 (1):1-64.
Farmer N, Hillier M, Kilby MD, Hodgetts-Morton V, Morris RK. Outcomes in intervention and management of multiple pregnancies trials: A systematic review. European Journal of Obstetrics & Gynecology and Reproductive Biology.2021;261:178–192. doi: 10.1016/j.ejogrb.2021.04.025.
Cao G, Liu J, Liu M. Global, Regional, and National Incidence and Mortality of Neonatal Preterm Birth, 1990-2019. JAMA Pediatr. 2022;176(8):787-796. doi:10.1001/jamapediatrics.2022.1622.
Xiong Q.-F, Yu Z.-H, Zhang A.-L, Zhu X.-H. Impact of maternal age on perinatal outcomes in twin pregnancies: a systematic review and meta-analysis Eur Rev Med Pharmacol Sci 2022; 26 (1): 99-109. doi: 10.26355/eurrev_202201_27753.
Cimpoca B, Syngelaki A, Chi Mu A, Savvoulidou E, Nicolaides KH. Twin pregnancy with two live fetuses at 11–13 weeks: effect of one fetal death on pregnancy outcome. Ultrasound Obstet Gynecol 2020; 55: 482–488. doi: 10.1002/uog.21925.
Lanna MM, Consonni D, Faiola S, Izzo G, Scelsa B, Cetin I, et al. Incidence of Cerebral Injury in Monochorionic Twin Survivors after Spontaneous Single Demise: Long-Term Outcome of a Large Cohort. Fetal Diagn Ther 2020; 47: 66–73. doi: 10.1159/000500774.
Mackie FL, Rigby A, Morris RK, Kilby MD. Prognosis of the co-twin following spontaneous single intrauterine fetal death in twin pregnancies: a systematic review and meta-analysis. BJOG 2019; 126: 569–578. doi: 10.1111/1471-0528.15530.
Berveiller P, Rousseau A, Rousseau M, Bitumba I, Goffinet F, Rozenberg P. Risk of preterm birth in a twin pregnancy after an early-term birth in the preceding singleton pregnancy: a retrospective cohort study. BJOG. 2020;127(5):591-598. doi: 10.1111/1471-0528.16071.
Awadalla MS, Salem WH, Ho JR, Cortessis VK, Ahmady A, Paulson RJ. Effects of parity on preterm delivery in twin gestations conceived with in vitro fertilization. F S Rep. 2023;4(1):49-54. doi: 10.1016/j.xfre.2023.01.005.
Gui Q, Yang Y, Wang L, Chen Y, Mei L, Xiang X, et al. A nomogram to predict preterm birth in twin pregnancies. Am J Transl Res. 2022;14(10):7119-7127.
Zhang J, Pan M, Zhan W, Zheng L, Jiang X, Xue X. Two-stage nomogram models in mid-gestation for predicting the risk of spontaneous preterm birth in twin pregnancy. Arch Gynecol Obstet. 2021;303(6):1439-1449. doi: 10.1007/s00404-020-05872-0.
Zhang J, Zhan W, Lin Y, Yang D, Li L, Xue X, et al. Development and external validation of a nomogram for predicting preterm birth at < 32 weeks in twin pregnancy. Sci Rep. 2021;11(1):12430. doi: 10.1038/s41598-021-91973-y.
Vieira LA, Warren L, Pan S, Ferrara L, Stone JL. Comparing pregnancy outcomes and loss rates in elective twin pregnancy reduction with ongoing twin gestations in a large contemporary cohort. Am J Obstet Gynecol. 2019;221(3):253.e1-253.e8. doi: 10.1016/j.ajog.2019.04.001.
Marleen S, Dias C, MacGregor R, Allotey J, Aquilina J, Khalil A, et al. Biochemical predictors of preterm birth in twin pregnancies: A systematic review involving 6077 twin pregnancies. Eur J Obstet Gynecol Reprod Biol. 2020;250:130-142. doi: 10.1016/j.ejogrb.2020.04.015.
Sun J, Li N, Jian W, Cao D, Yang J, Chen M. Clinical application of cervical shear wave elastography in predicting the risk of preterm delivery in DCDA twin pregnancy. BMC Pregnancy Childbirth. 2022;22(1):202. doi: 10.1186/s12884-022-04526-0.
Li C, Shen J, Hua K. Cerclage for women with twin pregnancies: a systematic review and metaanalysis. Am J Obstet Gynecol. 2019;220(6):543-557.e1. doi: 10.1016/j.ajog.2018.11.1105.
Rissanen AR.S, Jernman RM, Gissler M, Nupponen I, Nuutila ME. Maternal complications in twin pregnancies in Finland during 1987–2014: a retrospective study. BMC Pregnancy Childbirth. 2019;19:337. doi: 10.1186/s12884-019-2498-x