The recurrent miscarriage of pregnancy (RMP) is characterized by a wide range of variations in etio-logy, including immunological factors. Lymphocyte-immunotherapy is a method, the effectiveness of which for couples with early RMP has been studied since 1985. The results of the procedure are ambigu-ous and contradictory. However, numerous studies confirm the effectiveness of the method. This article analyzes the literature on the results of the use of lymphocyte-immunotherapy, indicating the immu-nological factors, the level of which varies during the normal course of pregnancy, her recurrent miscar-riage and after the application of the procedure.
Liu M., Zhen X., Song H., et al. Low-dose lymphocyte immunotherapy rebalances the peripheral blood Th1/Th2/Treg paradigm in patients with unexplained recurrent miscarriage. Reprod Biol Endocrinol. 2017;15(1):95. Published 2017 Dec 16. doi:10.1186/s12958-017-0315-9.
Yang F., Zheng Q., Jin L. Dynamic Function and Composition Changes of Immune Cells During Normal and Pathological Pregnancy at the Maternal-Fetal Interface // Frontiers in Immunology. 2019.V. 10. P. 2317. DOI=10.3389/fimmu.2019.02317.
Абламуниц В.Г. Механизмы толерантности матери к плоду: уроки молекулярной дипломатии // Проблемы репродукции. 2016;22(2): 8-16. DOI=10.17116/repro20162228-16.
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Pei CZ, Kim YJ, Baek KH. Pathogenetic factors involved in recurrent pregnancy loss from multiple aspects. Obstet Gynecol Sci. 2019;62(4):212-223. doi:10.5468/ogs.2019.62.4.212.
Малышкина А.И., Батрак Н.В. Факторы риска самопроизвольного прерывания беременности у женщин с привычным невынашиванием в анамнезе // Медицинский совет. 2015. №XX. C.46-49.
Батрак Н.В., Малышкина А.И. Факторы риска привычного невынашивания беременности // Вестник ИвГМА. 2016. № 4. С. 37-41.
Grimstad, F., Krieg, S. Immunogenetic contributions to recurrent pregnancy loss. J Assist Reprod Genet 33, 833–847 (2016). https://doi.org/10.1007/s10815-016-0720-6
Маркова А.С., Меньшиков И.В., Бедулева Л.В. и др. Клинико-диагностическая ценность методов определения иммунного ответа матери на антигены отца и установления толерантности при беременности // Вестник Удмуртского университета. Серия «Биология. Науки о Земле». 2011. №4. С. 102-106.
Meenakshi Singh, Jyoti Rajak, Shalaka Kadam and Sunil B. Rajadhyaksha (May 13th 2019). Alloimmunization and Role of HLA in Pregnancy, Complications of Pregnancy, Hassan Abduljabbar, IntechOpen, DOI: 10.5772/intechopen.84211.Available from: https://www.intechopen.com/books/complication-of-pregnancy/alloimmunization-and-role-of-hla-in-pregnancy.
Pandey, Manoj & Rani, Reena & Agrawal, Suraksha. (2005). An update in recurrent spontaneous abortion. Archives of gynecology and obstetrics. 272. 95-108. 10.1007/s00404-004-0706-y.
Pandey, Manoj & Thakur, Seema & Agrawal, Suraksha. (2004). Lymphocyte immunotherapy and its probable mechanism in the maintenance of pregnancy in women with recurrent spontaneous abortion. Archives of gynecology and obstetrics. 269. 161-72. 10.1007/s00404-003-0560-3.
Hajipour, H, Nejabati, HR, Latifi, Z, et al. Lymphocytes immunotherapy for preserving pregnancy: Mechanisms and Challenges. Am J Reprod Immunol. 2018; 80: e12853. https://doi.org/10.1111/aji.12853
Takeshita, Toshiyuki. (2004). Diagnosis and Treatment of Recurrent Miscarriage Associated with Immunologic Disorders: Is Paternal Lymphocyte Immunization a Relic of the Past? Journal of Nippon Medical School = Nippon Ika Daigaku zasshi. 71. 308-13. 10.1272/jnms.71.308.
Cavalcante, Marcelo & Sarno, Manoel & Da Silva Costa, Fabricio & Barini, Ricardo. (2016). Lymphocyte immunotherapy in the treatment of recurrent miscarriage: systematic review and meta-analysis. Archives of Gynecology and Obstetrics. 295. 1-8. 10.1007/s00404-016-4270-z.
Wong LF, Porter TF, Scott JR. Immunotherapy for recurrent miscarriage. Cochrane Database Syst Rev. 2014;2014(10):CD000112. Published 2014 Oct 21. doi: 10.1002/14651858.CD000112.pub3
Гинзбруг Б.Г. Лимфоцитотерапия как метод лечения пациенток с репродуктивными потерями при невынашивании беременности. РОССИЙСКИЙ ВЕСТНИК АКУШЕРА-ГИНЕКОЛОГА 1, 2015. 42-46. doi: 10.17116/rosakush201515142-46
Wang WJ (2014) Lymphocyte Immunotherapy is Not Necessary for Primary Unexplained Abortions. Reprod Syst Sex Disord 3: 132. doi:10.4172/2161-038X.1000132
Yang, K. & Zhang, B. & Lou, G.-Y & Wang, H.-D & Hou, Q.-F & He, M. & Chu, Y. & Chen, Y.-Q & Li, Q.-C & Zhang, C.-Y & Song, Y.-P & Liao, S.-X. (2017). The study of the prognostic value of mixed lymphocyte reaction blocking factor (MLR-Bf) for the pregnancy outcome after lymphocyte immunization in different kinds of patients with unexplained recurrent spontaneous abortion. International Journal of Clinical and Experimental Pathology. 10. 688-694.