Study of clinical instrumental and laboratory criteria for the prediction of preeclampsia in the first trimester of pregnancy

Abstract

Preeclampsia is one of the leading causes of maternal mortality. It is found after the 20th week of pregnancy and is characterized by hypertension, proteinuria, gestational edema, and eclampsia, leading to maternal death. The purpose of this article was to study the risk factors for preeclampsia, as well as to predict preeclampsia using diagnostic (Doppler) and laboratory markers (B-2 glycoprotein-1, XQ, PAPP - A, placental height factor ) until.
According to the results of the study, the presence of chronic hypertension in previous pregnancies (PV +100%), history of PE and eclampsia (PV + 83.3%), vaginal bleeding in current pregnancies (PV + 83.3%), a combination of 3 and more risk factors (PV + 85.2%) was assessed as a risk factor for preeclampsia. Precli-nical laboratory markers of preeclampsia include ele-vated B-2 glycoprotein-1 and XQ, decreased placen-tal growth factor, and decreased PAPP-A levels in the blood. The most important factors in the prog-nosis of hypertensive disorders were placental height factor (PV + 93.8%) and B-2 glycoprotein-1 (PV + 88.9%). Early dopplerometric indications for preeclampsia include dichroic carving and decreased uterine-double blood flow. Dopplerometric indica-tors of severe preeclampsia - RI up to 0.60 and dichrotic notch in both uterine arteries or RI between 0.61-0.70 and only one uterine artery with dichrotic notch and no dichrotic notch in the uterine arteries Above 0.70 - can be used as prognostic markers.