Modern methods of treatment of bacterial vaginosis and nonspecific vaginitis
Abstract
A total of 200 women of reproductive age with bacterial vaginosis and nonspecific vaginitis partici-pated in the trial. Patients were divided into 3 groups: 1-st group- 62 women taking Hexicon sup-positories, the 2nd group included 87 women who were prescribed a combination therapy, including Hexicon and Metronidazole, and the 3rd group included 51 women taking metronidazol supposito-ries. The high efficacy and safety of combination therapy has been established in a randomized multicenter prospective study. Polyethylene oxide in the composition Hexicon destroys the biofilm, enhances the activity of the main drug, resulting in increased sensitivity to antimicrobial agents.
References
Кира Е.Ф. Бактериальный вагиноз. — СПб.: ооо «нева-люкс», 2001.
Анкирская А.С. Неспецифический вагинит. Гинекология. 2005. № 4. С. 15—18.
Тихомиров А.Л. Бактериальный вагиноз. Всегда ли и только ли антибиотики? Consilium medicum. 2011; 13(6): 52–55.
Mengi S., Vohra P., Sawhney N., Singh V.A. Biofilms: a diagnostic challenge in pereistent infections. Int J of Research in Medical and Health Sciences 2013; 2: 3: 22—27.
Taj Y, Essa F, Aziz F, Kazmi S. Study on biofilm-form-ing properties of clinical isolates of Staphylococcus aureus. J Infect Dev Ctries. 2012;14;6(5):403-9.
Hale LP, Swidsinski A, Mendling W. Bacteria associated with bacterial vaginosis. N Engl J Med. 2006;Jan 12;354(2):202-3.
Swidsinski A, Verstraelen H, Loening-Baucke V, et al. Presence of a polymicrobial endometrial biofilm in patient with bacterial vaginosis. PLoS One. 2013;8(1).
Hoiby N, Bjarnsholt T, Moser C, Bassi GL, et al. ESCMID guideline for the diagnosis and treatment of biofilm infections. Ed by F. Allerberger. 2014; January 14, 2015.
М.Р. Рахматулина, И.А. Нечаева. Биопленки микроорганизмов и их роль в формировании резистентности к антибактериальным препаратам. Вестник дерматологии и венерологии 2015; (2): 58-62.23
Буданов ПВ. Современные принципы терапии бактериального вагиноза. Вопросы гинекологии, акушерства и перинатологии. 2012.
Bradshaw S, Morton AN, Hocking J, Garland SM, Morris MB, Moss LM, et al. High recurrence rates of bacterial vaginosis over the course of 12 months after oral metronidazole therapy and factors associated with recurrence. JID. 2006; 193:1478-8.
McClure E.M., Goldenberg R.L., Brandes N. The use of chlorhexidine to reduce maternal and neonatal mortality and morbidity in low-resource settings. Int. J. Gynaecol. Obstet. 2007; 97(2): 89–94.
Тетелютина Ф.К., Василькова Е.В., Шиляева Е.Г., Сушенцова Т.В. Прегравидарная подготовка при неспецифических воспалительных процессах наружных гениталий. Акушерство и гинекология. 2011; 6: 102–6.
Workowski K.A., Berman S. Centers for Disease Control and Prevention (CDC). Sexually transmitted diseases treatment guidelines, 2010. MMWR Recomm. Rep. 2010; 59 (RR-12): 1–110.
Кира E. Ф. Клиника и диагностика бактериального вагиноза. Акушерство и Гинекология. 1994; 2: 32-5
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