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The role of the immune state of the endometrium in the recurrent implantation disorders and miscarriages
##common.pageHeaderLogo.altText## Actual Questions of Modern Gynecology and Perinatology
Vol. 12 No. 1 (2025)
Original article

The role of the immune state of the endometrium in the recurrent implantation disorders and miscarriages

Published: March 5, 2025
DOI: https://doi.org/10.28942/mgpam.v12i1.158

Abstract

The immune response is strongly affected by metabolic and nutritional parameters, inflammatory exposures and autoimmune conditions, and age. Inflammatory health conditions, including intestinal microbial dysbiosis, hyperglycemia, metabolic
dysfunction, and dietary deficiencies, particularly vitamins A and D, can interfere with both innate and adaptive immunities and form readily tractable targets for infertility treatment. High-risk women with previous reproductive and pregnancy conditions are an obvious target for preconception care to boost immune function. Addressing these and related clinical, nutritional, and lifestyle considerations should form a key part of pregnancy planning

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Keywords

miscarriage, recurrent implantation failure, immune state of the endometrium, human chorionic gonadotropin, peripheral blood mononuclear cell düşük, təkrar implantasiya uğursuzluğu, enometrium, immun vəziyyət, insan xorionik gonadotropin, periferik qanda mononuklear hüceyrələr повторные неудачи имплантации, привычные выкидыши, иммунное состояние эндометрия, хорионический гонадотропин человека, мононуклеарные клетки периферической крови

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