Features of cellular immunity in newborns with cytomegalovirus infection
Abstract
Cytomegalovirus infection (CMVI) is gaining increasing significance in modern clinical medicine [1‐8]. As a cause of mortality in cases of monospecific disease origin or as a competing condition, CMVI ranks fourth after influenza, herpes, and adenovirus
infections. According to World Health Organization (WHO) data, in developing countries, 90‐100% of the population becomes infected with cytomegalovirus (CMV) during childhood [9]. The European regional bureau of WHO categorizes CMVI as a group of diseases that determine the future of infectious pathology. The relevance of CMVI is attributed to its widespread prevalence among pregnant women, high morbidity, and mortality among children, as well as a wide spectrum of clinical and pathological variants. The frequency of generalized forms of this disease, according to autopsy data, varies from 2.2% among children who died between 7 and 30 days of age to 63.4% among children who died in the first year of life.
References
Andronaco, D.W. Congenital Cytomegalovirus and Hearing Loss. // J. Obstet. Gynecol. Neonatal. Nurs. ‐ 2020 May; ‐vol. 49(3), ‐ p. 293‐304. PMID: 32259513 doi: 10.1016/j.jogn.2020.02.005.
Bardanzellu, F.; Fanos, V.; Reali, A. Human Breast Milk‐acquired Cytomegalovirus Infection: Certainties, Doubts and Perspectives. // Curr. Pediatr. Rev. ‐ 2019, ‐ vol.15, ‐p. 30‐41.
Barton, M., Forrester, A.M., McDonald, J. Update on congenital cytomegalovirus infection: Prenatal prevention, newborn diagnosis, and management. // Paediatr. Child. Health. ‐ 2020, ‐ vol. 25, ‐ p.395‐396.
Marsico, C.; Aban, I.; Kuo, H.; James, S.; Sanchez, P.; Ahmed, A.; Arav‐Boger, R.; Michaels, M.; Ashouri, N.; Englund, J.; et al. Blood viral load in symptomatic congenital cytomegalovirus infection.// J. Infect. Dis.‐ 2019, ‐ vol.219, ‐p. 1398‐1406.
Messinger, C.J., Lipsitch, M., Bateman, B.T., He, M. et al. Association Between Congenital Cytomegalovirus and the Prevalence at Birth of Microcephaly in the United States. // JAMA Pediatr. 2020.
Pesch, M.H., Kuboushek, K., McKee, M.M. et al. Congenital cytomegalovirus infection. // BMJ 2021; ‐ vol. 373:n1212 doi: https://doi.org/10.1136/bmj.n1212 (Published 03 June 2021)
Shoham, A.B., Schlesinger, Y., Miskin, I., Kalderon, Z. et al. Cytomegalovirus (CMV) seroprevalence among women at childbearing age, maternal and congenital CMV infection: policy implications of a descriptive, retrospective, community‐based study. // Israel Journal Health Policy Res.‐ 2023 Apr 25;12(1):16. doi: 10.1186/s13584‐023‐00566‐9. PMID: 37098565
Thigpen, J. Congenital Cytomegalovirus‐History, Current Practice, and Future Opportunities. // Neonatal. Netw. ‐ 2020, ‐ vol. 39, ‐ p. 293‐298.
Zhang, Xin‐Yan, Fang, Feng. Congenital human cytomegalovirus infection and neurologic diseases in newborns. // Chin. Med. J. (Engl), ‐ 2019 Sep 5; ‐ vol. 132(17), ‐ p. 2109‐2118. PMID: 31433331
Keywords
immune system
viruses
cytomegalovirus infection
cellular immunity yeni doğulmuş uşaq
immun sistemi
viruslar
sitomeqalovirus infeksiyası
hüceyrə immuniteti новорожденный, иммунная система
вирусы
цитомегаловирусная инфекция
клеточный иммунитет
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