Features of cellular immunity in newborns with cytomegalovirus infection

Abstract

Cytomegalovirus infection (CMVI) is gaining increasing significance in modern clinical medicine [1‐8]. As a cause of mortality in cases of monospecific disease origin or as a competing condition, CMVI ranks fourth after influenza, herpes, and adenovirus
infections. According to World Health Organization (WHO) data, in developing countries, 90‐100% of the population becomes infected with cytomegalovirus (CMV) during childhood [9]. The European regional bureau of WHO categorizes CMVI as a group of diseases that determine the future of infectious pathology. The relevance of CMVI is attributed to its widespread prevalence among pregnant women, high morbidity, and mortality among children, as well as a wide spectrum of clinical and pathological variants. The frequency of generalized forms of this disease, according to autopsy data, varies from 2.2% among children who died between 7 and 30 days of age to 63.4% among children who died in the first year of life.