Lipid emulsion therapy in recurrent miscarriages and implantation fails
Abstract
Numerous studies have found a positive correlation between chemical and clinical pregnancy, live birth frequency, and the benefit of LET in RID and RM associated with immunological disorders. Further studies are needed to optimize dosing and dosing intervals for routine administration.
References
Parijot Kumar, Kevin Marron and Conor Harrity. Intralipid therapy and adverse reproductive outcome: is there any evidence? in Reproduction and Fertility 28 Jul 2021.
Hanna Achache, Ariel Revel. Endometrial receptivity markers, the journey to successful embryo implantation. 2006 Nov Dec;12(6):731-46. doi: 10.1093/humupd/dml004. Epub 2006 Sep 18.
Paula Renata Bueno Campos Canella 1, Ricardo Barini 2, Patrícia de Oliveira Carvalho 1, Daniela Soares Razolli. Lipid emulsion therapy in women with recurrent pregnancy loss and repeated implantation failure: The role of abnormal natural killer cell activity. J Cell Mol Med 2021 Mar;25(5):2290-2296. doi: 10.1111/jcmm.16257. Epub 2021 Feb 5.
Dakhly DMR, Bayoumi YA, Sharkawy M, et al. Intralipid supplementation in women with recurrent spontaneous abortion and elevated levels of natural killer cells. Int J Gynaecol Obstet. 2016;135(3):324‐327. 10.1016/j.ijgo.2016.06.026 [PubMed] [CrossRef] [Google Scholar]
Tang AW, Alfirevic Z, Quenby S. Natural killer cells and pregnancy outcomes in women with recurrent miscarriage and infertility: a systematic review. Hum Reprod. 2011;26(8):1971‐1980.10.1093/humrep/der164 [PubMed]
Abdolmohammadi-Vahid S, Danaii S, Hamdi K, Jadidi-Niaragh F, Ahmadi M & Yousefi M 2016 Novel immunotherapeutic approaches for treatment of infertility. Biomedicine and Pharmacotherapy 84 1449–1459. (https://doi.org/10.1016/j.biopha.2016.10.062)
Coulam CB. Intralipid treatment for women with reproductive failures. Am J Reprod Immunol. 2020:e13290. Epub ahead of print. PMID: 32567756. 10.1111/aji.13290 [PubMed]
Mariee N., Li T.C., Laird S.M. Expression of leukaemia inhibitory factor and interleukin 15 inendometrium of women with recurrent implantation failure after IVF; correlation with the number of endometrial natural killer cells. Hum Reprod. 2012;27(7):1946‐1954. 10.1093/humrep/des134 [PubMed].
Roussev RG, Dons’koi BV, Stamatkin C, et al. Preimplantation factor inhibits circulating natural killer cell cytotoxicity and reduces CD69 expression: implications for recurrent pregnancy loss therapy. Reprod Biomed Online. 2013;26(1):79‐87. 10.1016/j.rbmo.2012.09.017 [PubMed] [CrossRef] [Google Scholar]
Lédée N., Vasseur C., Petitbarat M., et al. Intralipid® may represent a new hope for patients with reproductive failures and simultaneously an over‐immune endometrial activation. J Reprod Immunol. 2018;130:18‐22. 10.1016/j.jri.2018.09.050 [PubMed] [CrossRef] [Google Scholar]
Bertan Akar, Ozan Doğan, Emre Kole, Eray Çalışkan. EFFECT OF INTRAVENOUS LIPID (SMOFLIPID®) USE ALONG IN VITRO.FERTILIZATION (IVF) TREATMENT IN WOMEN WITH FAILED IVF CYCLES DESPITE GOOD QUALITY EMBRYO TRANSFER: CASE-CONTROL STUDY. Department of Obstetrics and Gynecology, Private Kocaeli Hospital, Kocaeli, Istanbul, Turkey. 3
October 2022.
Human Fertilisation and Embryology Authority UK Statistics for IVF and DI Treatment, Storage, and Donation 2020. https://www.hfea.gov.uk/media/3158/fertility-treatment-2018-trends-and-figures.pdf
Franasiak JM & Scott RT 2017 Contribution of immunology to implantation failure of euploid embryos. Fertility and Sterility 107 1279-1283. (https://doi.org/10.1016/j.fertnstert.2017.04.019)
King K., Smith S., Chapman M., Sacks G. Detailed analysis of peripheral blood natural killer (NK) cells in women with recurrent miscarriage. Hum Reprod. 2010;25(1):52‐58. 10.1093/humrep/dep349 [PubMed].
Bae HJ, Lee G.Y., Seong J.M., Gwak H.S. Outcomes with perioperative fat emulsions containing omega‐3 fatty acid: a meta‐analysis of randomized controlled trials. Am J Health Syst Pharm. 2017; 74(12):904‐918. 10.2146/ajhp151015
Simon A., Laufer N. Assessment and treatment of repeated implantation failure (RIF). J Assist Reprod Genet. 2012;29(11):1227‐1239. 10.1007/s10815-012-9861-4 [PMC free article] [PubMed].
Lipid emulsion therapy in women with recurrent pregnancy loss and repeated implantation failure: The role of abnormal natural killer cell activity Paula Renata Bueno Campos Canella | Ricardo Barini| Patrícia de Oliveira Carvalho | Daniela Soares R 14 December 2020.
Romy Ehrlich, M. Louise Hull, Jane Walkley and Gavin Sacks. Fertility & ReproductionVol. 01, No. 04, pp. 154-160 (2019). Intralipid Immunotherapy for Repeated IVF Failure.
Jawharah Al-Zebeidi, Mohammed Agdi, Sahar Lary, Solaiman Al-Obaid,Gamar Salim & Dania Al- Jaroudi. Effect of empiric intravenous intralipid therapy on pregnancy outcome in women with unexplained recurrent implantation failure undergoing intracytoplasmic sperm injection-embryo transfer cycle: a randomized controlled trial. Pages 131-134 | Received 06 Mar 2019, Accepted 10 Jun
, Published online: 21 Jun 2019.
Беспалова О.Н., Жернакова Т.С., Сельков С.А., Чепанов С.В.Оценка эффективности внутривенной терапии жировой эмульсией Интралипид у пациенток с ранними репродуктивными потерями. Научно-исследовательский институт акушерства, гинекологии и репродуктологии им. Д.О. Отта Том 71, No 5 (2022).
Jawharah Al-Zebeidi*, Sahar Lary, Dania Al-Jaroudi.The Effect of Fat Emulsion Intralipid 20% in Reproductive Outcome for Patients With Multiple. Implantation Failure. International Journal of Women’s Health and Reproduction Sciences.Vol. 6, No. 2, April 2018, 144-149.
Keywords
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