Methods of repair of receptivity of the endometrium

Abstract

Human embryo implantation is a three-stage process (apposition, adhesion and invasion) invol-ving synchronized crosstalk between a receptive en-dometrium and a functional blastocyst. This ovarian steroid-dependant phenomenon can only take place during the window of implantation, a self-limited period of endometrial receptivity spanning between days 20 and 24 of the menstrual cycle. Implantation involves a complex sequence of signalling events, consisting in the acquisition of adhesion ligands together with the loss of inhibitory components, which are crucial to the establishment of pregnancy. Histological evaluation, now considered to add little clinically significant information, should be replaced by functional assessment of endometrial receptivity. Endometrial receptivity plays a crucial role in the establishment of a healthy pregnancy in cycles of assisted reproduction. Endometrial receptivity disor-der requires a personalized approach to each patient.