Features of the hormonal activity of girls with hyperandrogenia syndrome during puberty

Abstract

Purpose of the study. To study the peculiarities of hormonal changes in girls with hyperandrogenia syndrome (HA) during puberty. Material and methods. 137 girls with HA syndrome were examined, of which 53.3% (n = 73) were diagnosed with polycystic ovary syndrome (PCOS), 19% (n = 26) with hyperprolactinemia, 15.3% (n = 21) of examined were obese. 5, 8% (n = 8) of girls had hypothyroidism, 3.6% (n = 5) follicular ovarian cyst, 1.5% (n = 2) congenital hyperplasia of the adrenal cortex, 1.5% (n = 2) had hypogonadotropic hypogonadism. All patients were conducted determination in the blood serum of indicators of follicle-stimulating (FSH), luteinizing (LH), thyroid-stimulating (TSH), adrenocorticotropic (ACTH) hormones. Indicators of prolactin (Prl), dehydroepiandrosterone sulfate (DHEA-S), cortisol (C), testosterone (T), estradiol (E2), 17-hydroxyprogesterone (17-OPR), triiodothyronine (T3), triiodothyroxine (T4) we’re determined as well. The results of the study. It was found out that in the dynamics of puberty, starting from 14-15 years, there was a statistically significant increase in the levels of LH, LH / FSH and DHEA-S when compared with physiological parameters. Also it was found out that girls with HA syndrome have low levels of FSH, LH, LH / FSH, T4 and a statistically significant increase in T, E2, DHEA-S, C, which mainly reflects the ovarian and adrenal origin of the HA syndrome.