Informative value of CA-125, HE4, CA 19-9, CA 15-3, CEA in the diagnosis of recurrent external genital endometriosis
Abstract
The goal of investigation was to study the Infor-mative value of various oncomarkers in the diagnosis of recurrent external genital endometriosis. Material and Methods: 48 patients with recurrent external genital endometriosis were examined. The average age of the patients was 34,96±1,1 years. The average duration of the disease was 10.0±1,4 years. The frequency of the recurrences was 2.02±0,44 years. The duration of the remission was 6,1±0,84 years. The comparative group was presented with 40 women with initially diagnosed external genital endomet-riosis. The average age of the examined was 33,56±1,16 years. All patients underwent immune-assay blood serum determination of the following markers: CA-125, HE4, CA 19-9, CA 15-3, CEA and ROMA index. Results: It was confirmed that there was significant decline in the parameters of CA 125 (31,21±1,36 U/ml) and CA 19-9 (15,96±0,25 U/ml) in comparison with initial cases of external genital endometriosis, at the same time there was increase in the parameters of CA 15-3 (14,1±0,33 U/ml)
References
Anastasi E., Granato T., Falzarano R., Storelli P. The use of HE4, CA-125 and CA72-4 biomarkers for differential diagnosis between ovarian endometrioma and epithelial ovarian cancer // Am.J.Ovarian Research., 2013, №6, p.44-51.
Müasir ginekologiya və perinatologiyanın aktual məsələləri 08 №03/2021
Chen T., Wei J.L., Leng T., Gao F. The diagnostic value of the combination of hemoglobin, CA 199, CA125, and HE4 in endometriosis // Am.J.Clin.Lab.Anal., 2021, p.2347-2354.
Зурочка А.В., Тиунова Т.А. Актуальные вопросы диагностики заболеваний молочных желез в крупном промышленном городе Челябинской области // Ж.Медицинская иммунология, 2015, т.17, №3, с.281-286.
Ceccaroni M., Bounous V.E., Clarizia R., Mautone D. Recurrent endometriosis: a battle against an unknown enemy // Eur. J. Cont,Reprod.Health Care, 2019, №24, p.464-474.
Kvaskoff M., Mhamat-Saleh Y., Farland L.V. Endometriosis and cancer: a systematic review and meta-analysis // Am.J.Hum.Reprod Update, 2021, №27, p.393-420.
Chapron C., Marcellin L., Borghese B., Santulli P. Rethinking mechanisms, diagnosis and management of endomtriosis // Nat.Rev.Endocrinol., 2019, №15, p.666-682.
Dai Y., Zhang J.J., Lang J.H. A convenience sampling questionnaire survery of the current status of diagnosis and treatment of endometriosis in China in 2018 // Zhonghua Fu Chan Ke Za Zhi, 2020, №55, p.402-407.
Granato T., Midulla C., Longo F., Colaprica B., Frati L. Role of HE4, CA 72-4, and CA-125 in monitoring ovarian cancer // Am.J.Tumor Biol., 2012, vol.33, №5, p.1335-1339.
Hamed E.O., Ahmed H., Sedeek O.B. Significance of HE4 estimation in comparison with CA-125 in diagnosis of ovarian cancer and assessment of treatment response // Am.J.Diagn Pathol., 2013, vol.8, №11, p.25-30.
McKinnon B., Muller M., Nirgianakis K., Bersinger N. Comparison of ovarian cancer markers in endometriosis favours HE4 over CA-125 // Am.J.Molecular Medicine Reporst, 2015, №12, p.5179-5184.
McLemore M.R., Aouzerat B.E., Lee K.A., Chen L.M. A comparison of the cyclic variation in serum levels of CA-125 across the menstrual cycle using two commercial assays // Am.J.Bio.Res.Nurs., 2012, №14, p.250-256.
Moore G., Miller M.C., Stenhoff M.M., Skates S.J.Serum HE4 levels are less frequently elevated than CA-125 in women with bening gynecologic disorders // Am.J.Obstet.Gynecol., 2012, vol.206, №4, p.351.
Raffi F., Metwally M., Amer S. The impact of excision of ovarian endometrioma on ovarian reserve: a systematic review and meta-analysis // Am.J.Clin.Endocrinol.Metab., 2012, vol.97, №9, p.3146-3154.
Vasilakaki T., Skafica E., Arkouman E., Grammatologlou X. Borderline clear cell adenofibroma of the ovary associated with ovarian endometriosis: a case report // Eur.J.Gynaecol.Oncol, 2012, vol.33, №2, p.230-232
Keywords
oncomarkers
CA 125, HE4, CA19-9, CA 15-3, ROMA index, CEA residivləşən xarici genital endometrioz
CA-125, HE4, ROMA indeksi, CA 15-3, CA 19-9
XEA onkomarkerləri рецидивирующий наружный генитальный эндометриоз
онкомаркеры
CA 125, HE4, CA19-9, CA 15-3, индекс ROMA, CEA
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