Clinical and diagnostic features of the combination of hyperprolactinemia and polycystic ovary syndrome

Abstract

Objective: The aim of the study was to investigate the frequency of occurrence and the clinical and diagnostic features of the combination of hyperprolactinemia (HP) and polycystic ovary syndrome (PCOS).
Material and methods: 69 girls and women with secondary hyporprolactinemic hypogonadism (HPHG) were examined. A combination of HP and PCOS was found in 20 (83.3%) patients. Clinical, hormonal, radiological methods were used for examination.
Results: It was established that the frequency of combination of syndromes of hyperprolactinemia and PCOS is 34.8%. In 20 patients (83.3%), HPHG and PCOS were marked by irregular menstruation, and in 4 (16.7%) menstrual cycles were regular. Disorders of the menstrual cycle wereopsomenorheain 65%, amenorrheain 25%, premenorrheain 10% cases. In 83.3% of patients, the combination of these syndromes was noted in menstruation disorders in the form of polymenorrhea (55%), menorrhagia in 25%, and oligomenorrhea in 20%. 16.7% of patients had menstruation without complications. In 86.7% (in 13) patients with HP and PCOS, infertility was observed, in 13.3% (in 2) patients, reproductive function was preserved.
As a result of a hormonal study, it was found that in patients with HP and PCOS, the presence of HA and a decrease in estradiol (E2) were noted. According to the ultrasound, there was a decrease in the echographic parameters of the uterus and a thickening of the endometrium (7.0 ± 0.63 mm). There was a significant increase in the length and thickness of both ovaries.