Predictor role of mucosal markers in prognosis of allergic diseases
Abstract
Aim of the current research is forecast atopic dermatitis formation based upon estimation of Mucosal intestinal secretion condition since first days in postnatal period. In neonatal period together with routine analyses in deoxygenated blood serum, taken by method of immune ferment analyses on 1-3 days after birth, we define levels of MUC-2 and ITF that in their turn reflect barrier condition of intestinal secretion. There were examined 414 full-term newborns with gestation age in 37-42 weeks. Hyper secretion of goblet cells exposed in high concentration of MUC-2 since first days of life allows assume of infringement intestinal Mucosal barrier under influence of perinatal risk factors in formation of atopic dermatitis at the next stages of ontogenesis. Obvious changes of MUC-2 level in compare to ITF data in atopic dermatitis reveal bigger sensitivity of the first component in intestinal barrier under infringement affection in antenatal period. These MUC-2 data are to be considered as biomarkers of forecast atopic dermatitis development in atopic prepossessed children.
References
Chu D, Ma J, Prince A. et al. Maturation of the infant microbiome community structure and function across multiple body sites and in relation to mode of delivery. Nature Medicine 2017; 23 (3): 314–326.
Gerner T, Halling AS, Rasmussen Rinnov M, Haarup Ravn N, Hjorslev Knudgaard M, Menné Bonefeld C, Ewertsen C, Trautner S, Jakaša I, Kezic S, Skov L, Thyssen JP. Barrier dysfunction in Atopic newBorns studY' (BABY): protocol of a Danish prospective birth cohort study.BMJ Open. 2020 Jul 12;10(7)
Hernández CD, Casanello P, Harris PR, Castro-Rodríguez JA, Iturriaga C, Perez-Mateluna G, Farías M, Urzúa M, Hernandez C, Serrano C, Sandoval M, Hoyos-Bachiloglu R, Uauy R, Borzutzky A. Early origins of allergy and asthma (ARIES): study protocol for a prospective prenatal birth cohort in Chile.BMC Pediatr. 2020 Apr 15;20(1)
Alfonso J, Pérez S, Bou R, Amat A, Ruiz I, Mora A, Escolano S, Chofre L. Asthma prevalence and risk factors in school children: The RESPIR longitudinal study. Allergol Immunopathol (Madr). 2020 May-Jun;48(3):223-231.
Looman KIM, van Meel ER, Grosserichter-Wagener C, Vissers FJM, Klingenberg JH, de Jong NW, de Jongste JC, Pasmans SGMA, Duijts L, van Zelm MC, Moll HA. Associations of Th2, Th17, Treg cells, and IgA(+) memory B cells with atopic disease in children: The Generation R Study. Allergy. 2020 Jan;75(1):178-187
Schoch JJ, Monir RL, Satcher KG, Harris J, Triplett E, Neu J. The infantile cutaneous microbiome: A review. Pediatr Dermatol. 2019 Sep;36(5):574-580.
Underwood MA. Should we treat every infant with a probiotic? Minerva Pediatr. 2019 Jun;71(3):253-262.
Yang G, Han YY, Forno E, Acosta-Pérez E, Colón-Semidey A, Alvarez M, Canino G, Chen W, Celedón JC. Under-diagnosis of atopic dermatitis in Puerto Rican children. World Allergy Organ J. 2019 Jan 26;12(1):100003.
Ku MS. Neonatal Phototherapy: A Novel Therapy to Prevent Allergic Skin Disease for at Least 5 Years. Neonatology. 2018;114(3):235-241.
