Platelet-rich plasma as a potential new strategy for the treatment of thin endometrium

Abstract

Though advances in assisted reproduction techniques (ART) have led to remarkable improvements in pregnancy rates, implantation failure has long been an unsolved problem. One-third of implantation failures can be attributed to embryo reasons, while unsatisfactory endometrial receptivity and poor embryo-endometrium communication account for the remaining two-thirds of such failures. Despite the great progress in embryo election and quality improvement, many patients are still undergoing repeated implantation failure (RIF). Poor endometrial receptivity has become a bottleneck issue in the ART field, and the lack of evidence-based treatments signifies the issue. Clinicians and scientists have struggled to find an effective therapeutic solution. Recently, increasing evidence has shown the positive role played by autologous platelet-rich plasma (PRP) in treating endometrium.