print ISSN: 2411-3956
The immunopathogenesıs of HBV and HCV infectıons
##common.pageHeaderLogo.altText## Actual Questions of Modern Gynecology and Perinatology

Abstract

This article provides an overview of current literature data on the immunopathogenesis of HBV, HCV infections. Increasing the frequency of HBV, HCV infections, and virus carrying in particular, created the need to develop new WHO projects on viral hepatitis. In the article the latest achievements in the fi eld of molecular virology and immunology concerning parenteral hepatitis are discussed. The leading role in the pathogenesis of diseases of the relationship between the molecular genetic structure of HBV, HCV and the immune, interferon, HLA systems of the body is noted. The study of the immunopathogenesis of HBV, HCV infections will help clinicians in the diff erentiation of clinical forms of these diseases, and in the future - the creation of conditions for the selection of optimal methods of treatment, the creation of vaccines for the prevention of HCV infection.

References

“Global Health Sector Strategy on Viral Hepatitis 2016-2021” World Health Organization June 2016, Document Production Servises, Geneva, Switz erland. p.11,12,13.

Park SH, Rehermann B. Immune responses to HCV and other hepatitis viruses. Immunity. 2014 Jan 16; 40(1): 13–24.doi: 10.1016/j.immuni.2013.12.010

“Global Hepatitis Proqramme “, updated version April 2016, 20 Avenue Appia, 1211, Geneva 27, Switz erland, 265 p. )

Мамедов М.К. « Вирусный гепатит С» Монография. Издание второе доп. Баку. «Элм» 2010.- 189с. (с.24).

Jeong Eun Song and Do Young Kim Diagnosis of hepatitis B. Ann Transl. Med. 2016 Sep; 4(18): 338.doi: 10.21037/atm.2016.09.11PMCID: PMC5066055

Luca G. Guidott i and Francis V. Chisari İmmunobiology and pathogenesis of viral hepatitis. Annual Review of Pathology Mechanizms of disease. Vol. 1. 23-61. 28 February 2006 htt ps .// doi. 10.1146/annurev.pathol. 1. 110304. 106230 .

Dunn C, Brunett o M, Reynolds G, Christophides T, Kennedy PT, Lampertico P, Das A, Lopes AR, Borrow P, Williams K, Humphreys E, Aff ord S, Adams DH, Bertolett i A, Maini MK

“Cytokines induced during chronic hepatitis B virus infection promote a pathway for NK cell–mediated liver damage “ (Jour. Exp Med. 2007 Mar 19; 204(3): 667–680. doi: 10.1084/

jem.20061287

Zhang N, Bevan MJ. CD8(+) T cells: foot soldiers of the immune system. Immunity. 2011;35:161–168. doi: 10.1016/j.immuni.2011.07.010.)

Youngblood B, Hale JS, Ahmed R. T-cell memory diff erentiation: insights from transcriptional signatures and epigenetics. Immunology. 2013;139:277–284. doi: 10.1111/imm.12074.

Maini MK, Boni C, Lee CK, Larrubia JR, Reignat S, Ogg GS, et al. The role of virus-specifi c CD8(+) cells in liver damage and viral control during persistent hepatitis B virus infection. J Exp Med. 2000;191:1269–1280. doi: 10.1084/jem.191.8.1269.

Ferrari C, Penna A, Bertolett i A, Valli A, Antoni AD, Giuberti T, et al. Cellular immune response to hepatitis B virus-encoded antigens in acute and chronic hepatitis B virus infection. J Immunol. 1990;145:3442–3449.

Bertolett i A, Costanzo A, Chisari FV, Levrero M, Artini M, Sett e A, et al. Cytotoxic T lymphocyte response to a wild type hepatitis B virus epitope in patients chronically infected

by variant viruses carrying substitutions within the epitope. J Exp Med. 1994;180:933–943. doi: 10.1084/jem.180.3.933.

Webster GJ, Reignat S, Brown D, Ogg GS, Jones L, Seneviratne SL, et al. Longitudinal analysis of CD8+ T cells specifi c for structural and nonstructural hepatitis B virus proteins in patients with chronic hepatitis B: implications for immunotherapy. J . Virol. 2004;78:5707–5719. doi: 10.1128/JVI.78.11.5707-5719.2004.

Lopes AR, Kellam P, Das A, Dunn C, Kwan A, Turner J, et al. Bim-mediated deletion of antigen-specifi c CD8 T cells in patients unable to control HBV infection. J Clin Invest.

;118:1835–1845. doi: 10.1172/JCI33402

Appay V, Van Lier RA, Sallusto F, Roederer M. Phenotype and function of human T lymphocyte subsets: consensus and issues. Cytometry A. 2008;73:975–983. doi: 10.1002/

cyto.a.20643

Boni C, Fisicaro P, Valdatt a C, Amadei B, Di Vincenzo P, Giuberti T, et al. Characterization of hepatitis B virus (HBV)-specifi c T-cell dysfunction in chronic HBV infection. J Virol.

;81:4215–4225. doi: 10.1128/JVI.02844-06.

Fisicaro P, Valdatt a C, Massari M, Loggi E, Biasini E, Sacchelli L, et al. Antiviral intrahepatic T-cell responses can be restored by blocking programmed death-1 pathway in chronic hepatitis B. Gastroenterology. 2010;138:682–693. e1-e4. doi: 10.1053/j.gastro.2009.09.052

Еналеева Д.Ш., Фазылов В.Х., Созинов А.С. « Хронические вирусные гепатиты В, С и D » Руководство для врачей. М. : МЕДпрессинформ, 2011. – 464с. (стр. 46. )

Gulay,Börekçi,Serap Yalın,Özlem Kandemir,Sevim Karakaş Çelik, Mehmet Berköz,Nurcan Araz “Kronik hepatit B və C enfeksiyonu ilə interlökin- 2 (-330) gen polimorfi zmi arasındakı ilişkinin araştırıması” Gazi Medical Journal, Türkiye,2016; 27;185-188 doi: htt :// dx.doi. org.12996/gmj.

Linderbach BD, Rice CM. The ins and outs of hepatitis C virus entry and accembly. Nature reviews Microbiology, 2013; 11(10); 688-700. pmid: 24018384

Hepatitis C virus core, NS3, NS4B and NS5A are the major immunogenic proteins in humoral immunity in chronic HCV infection” Maarit Sillanpää, Krister Melén,Päivi Porkka, Riku Fagerlund, Kaisu Nevalainen, Maija Lappalainen , Ilkka Julkunen .Virology Journal2009 6:84 htt ps://doi.org/10.1186/1743-422X-6-84 .

Сухно А.С. «Моделирование инфекции, вызванной вирусом гепатита С у мышей» Автореферат диссертации на соискание ученой степени кандидата биологических

наук. Москва, 2007, 23 стр.

Rehermann B. Hepatitis C virus innate and adaptive immune responses: a tale of coevolution and coexistense. The Journal of Clinical investigation. 2009; 119(7): 1745-54. pmid: 19587449. Doi 10.1172/ JC 139133.

Heim MH, Thimme R. Innate and adaptive immune responses in HCV infections. Journal of Hepatology . 2014; Nov. 61 (1 suppl): p.14-25. Pmid: 25443342. Doi 10.106/j j hep.2014

Н.В.Давидович, Н. В. Соловьева «Иммунный ответ при вирусном гепатите С: ведущая роль натуральных киллеров» « Вестник Северного Арктического Федерального Университета» Серия «Естественные науки» -2015.- №1 стр.68-78.

Joo Chun Yoon , Chang Mo Yang, Youkyoung Song, Jae Myun Lee “ Natural killer cells in hepatitis C: Current progress” World J. Gastroenterol. Jan. 28, 2016; 22 (4): 1449-1460 doi: 10.3748 / wjg. v. 22. Pmid: 26819513.

Rehermann B. Pathogenesis of chronic viral hepatitis: diff erential roles of T cells and NK cells. Nature medicine. 2013; 19 (7); 859-68 doi 10.1038/ nm 3251.

Kim H, Bose SK, Meyer K, Ray R. Hepatitis C virus impairs natural killer cell –mediated augmentation of complement synthesis Journal of Virology. 2014; 88(5); 2564-71 . doi 10. 1128/ JVI. 02988-13. pmid: 24352446.

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Keywords

HBV and HCV infections
immunopathogenesis HBV HCV infeksiyaları
immunopatogenez Инфекции HBV и HCV
иммунопатогенез